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Frequently Asked Questions

Although your doctor is the best source for answering your specific questions about migraines and treatment with RELPAX, you can find answers to common questions here.

General Information About RELPAX

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What is RELPAX?

RELPAX is indicated for the acute treatment of migraine with or without aura in adults.

How quickly does RELPAX work?

Many people feel relief with RELPAX in 2 hours.†‡ For some people, RELPAX starts to work in 30 minutes.§

Pain relief was measured in terms of headache response, defined as a reduction from severe or moderate headache to mild headache or no pain after medication.

The percentage of people achieving headache response at 2 hours after treatment was studied across 7 adult studies. Please see full Prescribing Information and Patient Information for a description of the results from these studies.

§9% of patients reported headache response with RELPAX 40 mg at 30 minutes (P=.0001 vs placebo).

Does RELPAX provide migraine symptom relief?

Yes, RELPAX reduces migraine symptoms. Patients treated with RELPAX experienced less nausea and sensitivity to sound and light compared with placebo.

How does RELPAX work?

RELPAX is believed to:

  • Reduce swelling of blood vessels
  • Block the release of chemicals in the brain that cause more pain
  • Block other symptoms of migraine pain

How to Get Brand-Name RELPAX

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How can I ensure that I won’t get switched to a generic substitute?

Here are 3 suggested tips to help make sure you receive brand-name RELPAX and not a generic:

  1. At your doctor’s office: Ask your doctor to prescribe brand-name RELPAX and to indicate “DAW” (Dispense As Written)—or the language used in your state—on all of your RELPAX prescriptions.
  2. At your pharmacy’s drop-off: Tell the pharmacist that you want brand-name RELPAX—and be sure to use the RELPAX Savings Card. The RELPAX Savings Card can only be used with brand-name RELPAX.
  3. At your pharmacy’s pick-up: Check your pills to be sure they’re brand-name RELPAX—not the generic—and also check that you’ve saved on your prescription.

What should I do if I receive a generic substitute instead of brand-name RELPAX?

Talk to your doctor and/or your pharmacist to ask if you should be getting brand-name RELPAX.

How do I know if I received brand-name RELPAX?

Check your pills for the distinctive shape and markings of brand-name RELPAX.

Saving on RELPAX

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What is the RELPAX Savings Card?

The RELPAX Savings Card allows eligible patients to pay as little as $4 every time they get a 30-day fill of brand-name RELPAX—and could save up to $1,800 a year. If you have a prescription for brand-name RELPAX, you can use the card for every fill through December 31, 2020.*

*Terms and conditions apply.

How do I use the RELPAX Savings Card?

There are 2 ways to use the card immediately. Once you’ve activated your Savings Card, you can either:

  • Bring a printed copy of it to the pharmacy
  • Show it to your pharmacist on your phone

You can keep this card with you and continue to save on each fill for RELPAX through December 31, 2020.

Who is eligible to use the RELPAX Savings Card?

To be eligible to use a RELPAX Savings Card, you must:

  • Be 18 years of age or older
  • Not be a resident of Massachusetts
  • Not be covered by Medicare, Medicaid, or any other federal or state healthcare programs
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The Card is not valid for California residents whose prescriptions are covered in whole or in part by third-party insurance, a healthcare service plan, or other health coverage where a lower cost generic is available, unless applicable step therapy or prior authorization requirements have been completed.

Please check with your healthcare professional or insurer to confirm eligibility.

To learn the full details of who is eligible, please see the full Terms and Conditions.

How do I get a RELPAX Savings Card?

To get a Savings Card, register here and then download your card or have it sent to you via mail, email, or text.

If I already have a RELPAX Savings Card, how can I activate it?

You can activate your Savings Card here.

Can I use the RELPAX Savings Card on a previously filled prescription?

The RELPAX Savings Card can only be used for new prescriptions that are filled after you have activated the card.

Does the RELPAX Savings Card work at nonparticipating pharmacies?

Yes, for reimbursement when using a nonparticipating pharmacy: Pay for your RELPAX prescription, and mail a copy of the original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: Pfizer, ATTN: RELPAX, PO Box 4937, Warren, NJ 07059-6600. Be sure to include a copy of the front of your RELPAX Savings Card, your name, and mailing address.

Does the RELPAX Savings Card work through mail-order pharmacies?

Yes, for reimbursement when using the RELPAX Savings Card through a mail-order pharmacy: Pay for your RELPAX prescription, and mail a copy of the original pharmacy receipt (cash register receipt NOT valid) with product name, date, and amount circled to: Pfizer, ATTN: RELPAX, PO Box 4937, Warren, NJ 07059-6600. Be sure to include a copy of the front of your RELPAX Savings Card, your name, and mailing address.

Taking RELPAX

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When should I start taking RELPAX?

Treat early. When you take RELPAX is important. RELPAX provides the most migraine relief when taken at the first sign of pain.

How do I take RELPAX?

Always carry 2 doses of RELPAX with you. Migraines can hit when you least expect them.

Take 1 whole tablet, with or without food, as soon as you feel a migraine coming on. If your migraine improves, but then it comes back after 2 hours, you can take another dose of RELPAX.

Do not take more than 2 RELPAX 40-mg tablets within 24 hours.

Safety & Possible Side Effects

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What is the most important information I should know about RELPAX?

RELPAX can cause serious side effects, including:

Heart attack and other heart problems. Heart problems may lead to death.

Stop taking RELPAX and get emergency medical help right away if you have any of the following symptoms of a heart attack:

  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • chest pain or chest discomfort that feels like an uncomfortable heavy pressure, squeezing, fullness, or pain
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded


RELPAX is not for people with risk factors for heart disease unless a heart exam is done and shows no problem.

You have a higher risk for heart disease if you:

  • have high blood pressure
  • have high cholesterol levels
  • smoke
  • are overweight
  • have diabetes
  • have a family history of heart disease
  • are a female who has gone through menopause
  • are a male over age 40


Serotonin syndrome. Serotonin syndrome is a serious and life-threatening problem that can happen in people taking RELPAX, especially if RELPAX is taken with anti-depressant medicines called selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs).

Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Call your doctor right away if you have any of the following symptoms of serotonin syndrome:

  • mental changes such as seeing things that are not there (hallucinations), agitation, or coma
  • fast heartbeat
  • changes in blood pressure
  • high body temperature
  • tight muscles
  • trouble walking
  • nausea, vomiting, or diarrhea

Who should not take RELPAX?

Do not take RELPAX if you:

  • have heart problems or a history of heart problems
  • have or have had a stroke or problems with your blood circulation
  • have hemiplegic or basilar migraines. If you are not sure if you have these types of migraines, ask your doctor
  • have narrowing of the blood vessels in your legs, arms, stomach, or kidney (peripheral vascular disease)
  • have ischemic bowel disease
  • have uncontrolled high blood pressure
  • have taken any of the following medicines in the last 24 hours:
    • other “triptans” or triptan combination products such as:
      • almotriptan (Axert®)
      • frovatriptan (Frova®)
      • naratriptan (Amerge®)
      • rizatriptan (Maxalt®)
      • sumatriptan (Imitrex®)
      • sumatriptan and naproxen sodium, (Treximet®)
      • zolmitriptan (Zomig®)
    • ergotamines such as:
      • Bellergal-S®
      • Cafergot®
      • Ergomar®
      • Wigraine®
    • dihydroergotamines such as:
      • D.H.E. 45® or Migranal® or methysergide (Sansert®)
  • have taken the following medicines within the last 72 hours:
    • ketoconazole (Nizoral®)
    • itraconazole (Sporanox®)
    • nefazodone (Serzone®)
    • troleandomycin (TAO®)
    • clarithromycin (Biaxin®)
    • ritonavir (Norvir®)
    • nelfinavir (Viracept®)
  • are allergic to eletriptan or any of the ingredients in RELPAX


Please see full Prescribing Information and Patient Information for a complete list of ingredients in RELPAX.

All brands are trademarks of their owners.

What are the possible side effects of RELPAX?

RELPAX may cause serious side effects. See What is the most important information I should know about RELPAX?

These serious side effects include:

  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome)
  • stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:
    • sudden or severe stomach pain
    • stomach pain after meals
    • weight loss
    • nausea or vomiting
    • constipation or diarrhea
    • bloody diarrhea
    • fever
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:
    • cramping and pain in your legs or hips
    • feeling of heaviness or tightness in your leg muscles
    • burning or aching pain in your feet or toes while resting
    • numbness, tingling, or weakness in your legs
    • cold feeling or color changes in 1 or both legs or feet
  • medication overuse headaches. Some people who take too many RELPAX may have worse headaches (medication overuse headache). If your headaches get worse, your doctor may decide to stop your treatment with RELPAX


The most common side effects of RELPAX include:

  • dizziness
  • nausea
  • weakness
  • tiredness
  • drowsiness


Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of RELPAX. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

About Migraines

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What are migraines?

A migraine isn’t just a bad headache. It’s an intense, throbbing pain, usually felt on one side of the head. Some people also get nauseous and experience sensitivity to light and sound. The symptoms of migraine are thought to be caused by a complex series of neurological events that also appear to affect the blood vessels in the head.

What are the different types of migraines?

  • Migraines without aura

Not all migraines are the same. But many people experience:

  • Throbbing pain
  • Sensitivity to light and/or sound
  • Nausea
  • Migraines with aura

An aura is a feeling or series of sensations that come before a migraine attack and can last about 5-60 minutes.

Common symptoms of aura include:

  • Seeing flashing lights, zigzag lines, or blind spots
  • Feeling numbness or tingling in the face or hands
  • Speech disturbances

The aura may be followed by some or all of the symptoms of a migraine without aura.

Start the conversation. Keep a diary to track when you experienced the migraine, what you did and ate that day, and if you took any medication. The more your doctor knows about your headaches and symptoms, the more he or she can help determine if you suffer from migraines.

Who gets migraines?

If you get migraines, you’re not alone. More than 39 million people in the United States have migraines. Women are 2 times as likely as men to suffer from migraines. In fact, 15% of women and 6% of men are afflicted over a 1-year period. Migraines are most often seen in adults 18 to 44 years of age.

What are migraine triggers?

Triggers are things that can bring on migraines. They vary from person to person. Often it’s a combination of triggers that can set off an attack. Common triggers may be related to your diet, body, and environment.

  • Dietary
    • Aged cheeses
    • Soy products
    • Hot dogs
    • Lunch meats
    • Alcohol (often red wine)
    • Caffeine (too much or withdrawal)
    • Skipped meals
    • Monosodium glutamate (MSG, found in some canned and processed foods)
    • Aspartame (artificial sweetener)
  • Physical
    • Feeling worn down
    • Hormone changes
    • Being tired
    • Stress
    • Too much or too little sleep
  • Environmental
    • Weather changes
    • Light (bright, fluorescent, flashing, or flickering)
    • Odors and pollution (smog, smoke, perfume, chemical odors)

What are migraine symptoms?

Migraines can cause throbbing headaches that can vary in intensity. However, they can also be accompanied by sensitivity to light and sound, as well as nausea.

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