*Some exclusions apply. See full Terms and Conditions. Please note: This co-pay card is not health insurance and is only accepted at participating pharmacies. Savings limited to $100 per month for 12 uses. Card may be used once per month. For help with the RELPAX $4 Co-pay Card, call 1-800-926-5334, or write: Pfizer, ATTN: RELPAX, PO Box 4937, Warren, NJ 07059. www.pfizer.com
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WHAT IS RELPAX?

RELPAX is indicated for the acute treatment of migraine with or without aura in adults.
RELPAX is also the #1 prescribed branded triptan for the indication of acute migraines.

Works Fast and Lasts

Most people feel relief with RELPAX in 2 hours.*

For some people, RELPAX starts to work in 30 minutes..‡

Migraine Symptom Relief

RELPAX reduces migraine symptoms. Patients treated with RELPAX experienced less nausea and sensitivity to sound and light compared with placebo.

 

*Pain relief was measured in terms of headache response, defined as a reduction
from severe or moderate headache to mild headache or no pain after medication.

The percentage of people achieving headache response at 2 hours after treatment was studied across 7 adult studies. Please see full Prescribing Information and Patient Information for a description of the results from these studies.

9% of patients reported headache response with RELPAX 40 mg at 30 minutes (P=.0001 vs placebo).

 

Superior Pain Relief vs Imitrex® (sumatriptan succinate) 100 mg

In 2 clinical trials, more people taking RELPAX 40 mg experienced migraine pain relief at both 2 and 24 hours compared with those taking Imitrex 100-mg tablets.§

Imitrex is a registered trademark of GlaxoSmithKline.

§Pain relief was measured in terms of headache response, defined as a reduction from severe or moderate headache to mild headache or no pain after medication.

 

Patient Preferred

When asked if they would take their medication again to treat migraine attacks, more people said “yes” to RELPAX 40 mg than those taking Imitrex® 100-mg tablets.||

||As shown in 2 double-blind, placebo-controlled studies involving 2887 patients.

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HOW DOES RELPAX WORK?

RELPAX is believed to:

  • Reduce swelling of blood vessels
  • Block the release of chemicals in the brain that cause more pain
  • Block other symptoms of migraine pain
 

Getting the Most Out of RELPAX

It’s important to know which medicines you should not take with RELPAX. Read the list of medications to avoid taking with RELPAX.

In order to get the most out of your RELPAX treatment:

Treat early

When you take RELPAX is important. RELPAX provides the most migraine relief when taken at the first sign of pain.

Be prepared

Always carry 2 doses of RELPAX with you. Migraines can hit when you least expect them.

Take 1 whole tablet, with or without food, as soon as you feel a migraine coming on. If your migraine improves, but then it comes back after 2 hours, you can take another dose of RELPAX.

Do not take more than 2 RELPAX 40-mg tablets within 24 hours.

Fill your prescription in advance

Don’t wait until you run out of RELPAX to refill your prescription.

When you’re down to 2 pills, consider contacting your doctor to refill your prescription.

By taking this step, you will be prepared whenever a migraine strikes.

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What Is the Most Important Information I Should Know About RELPAX?

RELPAX can cause serious side effects, including:

Heart attack and other heart problems. Heart problems may lead to death.

Stop taking RELPAX and get emergency medical help right away if you have any of the following symptoms of a heart attack:

  • discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back
  • chest pain or chest discomfort that feels like an uncomfortable heavy pressure, squeezing, fullness, or pain
  • pain or discomfort in your arms, back, neck, jaw, or stomach
  • shortness of breath with or without chest discomfort
  • breaking out in a cold sweat
  • nausea or vomiting
  • feeling lightheaded

RELPAX is not for people with risk factors for heart disease unless a heart exam is done and shows no problem.
 You have a higher risk for heart disease if you:

  • have high blood pressure
  • have high cholesterol levels
  • smoke
  • are overweight
  • have diabetes
  • have a family history of heart disease
  • are a female who has gone through menopause
  • are a male over age 40

Serotonin syndrome. Serotonin syndrome is a serious and life-threatening problem that can happen in people taking RELPAX, especially if RELPAX is taken with anti-depressant medicines called selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs).

Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Call your doctor right away if you have any of the following symptoms of serotonin syndrome:

  • mental changes such as seeing things that are not there (hallucinations), agitation, or coma
  • fast heartbeat
  • changes in blood pressure
  • high body temperature
  • tight muscles
  • trouble walking
  • nausea, vomiting, or diarrhea
 

Who Should Not Take RELPAX?

Do not take RELPAX if you:
  • have heart problems or a history of heart problems
  • have or have had a stroke or problems with your blood circulation
  • have hemiplegic or basilar migraines. If you are not sure if you have these types of migraines, ask your doctor
  • have narrowing of the blood vessels in your legs, arms, stomach, or kidney (peripheral vascular disease)
  • have ischemic bowel disease
  • have uncontrolled high blood pressure
  • have taken any of the following medicines in the last 24 hours:
    • other “triptans” or triptan combination products such as:
      • almotriptan (Axert®)
      • frovatriptan (Frova®)
      • naratriptan (Amerge®)
      • rizatriptan (Maxalt®)
      • sumatriptan (Imitrex®)
      • sumatriptan and naproxen sodium, (Treximet®)
      • zolmitriptan (Zomig®)
    • ergotamines such as:

      • Bellergal-S®
      • Cafergot®
      • Ergomar®
      • Wigraine®
    • dihydroergotamines such as:
      • D.H.E. 45® or Migranal® or methysergide (Sansert®)
  • have taken the following medicines within the last 72 hours:
    • ketoconazole (Nizoral®)
    • itraconazole (Sporanox®)
    • nefazodone (Serzone®)
    • troleandomycin (TAO®)
    • clarithromycin (Biaxin®)
    • ritonavir (Norvir®)
    • nelfinavir (Viracept®)
  • are allergic to eletriptan or any of the ingredients in RELPAX.

Please see full Prescribing Information and Patient Information
 for a complete list of ingredients in RELPAX.

All brands are trademarks of their owners.

What Are the Possible Side Effects of RELPAX?

RELPAX may cause serious side effects. See “What Is the Most Important Information I Should Know About RELPAX?”

These serious side effects include:

  • changes in color or sensation in your fingers and toes (Raynaud’s syndrome).
  • stomach and intestinal problems (gastrointestinal and colonic ischemic events). Symptoms of gastrointestinal and colonic ischemic events include:

    • sudden or severe stomach pain
    • stomach pain after meals
    • weight loss
    • nausea or vomiting
    • constipation or diarrhea
    • bloody diarrhea
    • fever
  • problems with blood circulation to your legs and feet (peripheral vascular ischemia). Symptoms of peripheral vascular ischemia include:
    • cramping and pain in your legs or hips
    • feeling of heaviness or tightness in your leg muscles
    • burning or aching pain in your feet or toes while resting
    • numbness, tingling, or weakness in your legs
    • cold feeling or color changes in 1 or both legs or feet
  • medication overuse headaches. Some people who take too many RELPAX may have worse headaches (medication overuse headache). If your headaches get worse, your doctor may decide to stop your treatment with RELPAX.
The most common side effects of RELPAX include:
  • dizziness
  • nausea
  • weakness
  • tiredness
  • drowsiness

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of RELPAX. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

 

Here is a list of medicines you should not take with RELPAX. Patients should always ask their doctors for advice on adverse events.

You may report an adverse event related to Pfizer products by calling 1-800-438-1985 (U.S. only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.

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IMPORTANT SAFETY INFORMATION

Do not take RELPAX® (eletriptan HBr) if you:

  • Have heart disease or a history of heart disease
  • Have a history of stroke, transient ischemic attack
  • Have a history or current evidence of hemiplegic or basilar migraines (if you are not sure about this, ask your doctor)
  • Have peripheral vascular disease (e.g. narrowing of blood vessels to the legs, arms, stomach, intestines, or kidneys)
  • Have ischemic bowel disease (inadequate blood supply to the intestine)
  • Have uncontrolled blood pressure
  • Have taken other migraine medications in the last 24 hours, including other triptans, ergots, or ergot-type medications
  • Are allergic to RELPAX or any of its ingredients
  • RELPAX should not be used within at least 72 hours of treatment with the following medicines: Nizoral® (ketoconazole), Sporanox® (itraconazole), Serzone® (nefazodone), TAO® (troleandomycin), Biaxin® (clarithromycin), Norvir® (ritonavir), and Viracept® (nelfinavir)

All brands are trademarks of their owners.

Patients taking RELPAX may experience serious side effects, including:

Heart attacks and other heart problems. Heart problems may lead to death. Stop taking RELPAX and get emergency medical help right away if you have any symptoms of heart attack like discomfort in the center of your chest that lasts for more than a few minutes, or that goes away and comes back; chest pain or chest discomfort that feels like an uncomfortable heavy pressure; squeezing, fullness, or pain; pain or discomfort in your arms, back, neck, jaw, or stomach; shortness of breath with or without chest discomfort; breaking out in a cold sweat; nausea or vomiting; feeling lightheaded.

Medication overuse headaches. Some patients who take too many RELPAX may have worse headaches. If your headaches get worse your doctor may decide to stop your treatment with RELPAX.

Serotonin syndrome is a serious and life-threatening problem that can happen when taking RELPAX, especially when used with certain medications commonly used to treat depression such as selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs). Tell your doctor right away if you experience mental changes such as hallucinations, fast heartbeat, high body temperature, trouble walking, or nausea, vomiting or diarrhea.

Changes in color or sensation in your fingers and toes (Raynaud’s syndrome).

Stomach and intestinal problems like sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, fever.

Problems with blood circulation to your legs and feet (cramping and pain in your legs or hips); like feeling of heaviness or tightness in your leg muscles, burning or aching in your feet or toes while resting, numbness, tingling, or weakness in your legs, cold feeling or color changes in 1 or both legs or feet.

Most common side effects are dizziness, nausea, weakness, tiredness and drowsiness. If you have these symptoms, do not drive a car or do anything where you need to be alert. Tell your doctor about any side effects you have.

RELPAX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

INDICATION

RELPAX (eletriptan HBr) is indicated for the acute treatment of migraine with or without aura in adults. RELPAX should only be used where a clear diagnosis of migraine has been established. RELPAX is not for the prevention of migraines or other types of headaches, including cluster headache.

Click here for the full Prescribing Information and Patient Information for RELPAX.

You may report an adverse event related to Pfizer products by calling 1-800-438-1985 (U.S. only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088.